Sapolio was a brand of soap noted for its advertising, led by Artemas Ward from 1883–1908. Bret Harte wrote jingles for the brand, and the sales force also included King Camp Gillette, who went on to create the Gillette safety razor and the razor and blades business model. Time magazine described Sapolio as "probably the world's best-advertised product" in its heyday.

Sapolio was manufactured by Enoch Morgan's Sons Co. from 1869, and named by the family doctor.

In 1997, Sapolio was bought by the Peruvian company Intradevco Industrial SA. Intradevco is owner of the Sapolio brand in more of 80 countries. The Sapolio brand name is now used to market several cleaning products in Peru, Chile and USA.
North Peruvian Group is a distributor of the brand in the USA.

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